4-Bromo-2-methylpyridine → 1-(5-Bromo-2-fluorophenyl)-4-fluoro-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine

HRID 1662180ノート

反応式

HRID 1662180 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:25])=[C:6]([C:8]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:17]=2[C:23]#[N:24])=[N:9]S(C(C)(C)C)=O)[CH:7]=1.Br[C:27]1[CH:32]=[CH:31][N:30]=[C:29]([CH3:33])[CH:28]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:25])=[C:6]([C:8]2([C:27]3[CH:32]=[CH:31][N:30]=[C:29]([CH3:33])[CH:28]=3)[C:16]3[C:17](=[C:18]([F:22])[CH:19]=[CH:20][CH:21]=3)[C:23]([NH2:24])=[N:9]2)[CH:7]=1

参加物

3

反応物 2

HCID 27628354-Bromo-2-methylpyridineHCID 76821600N-((5-bromo-2-fluorophenyl)(2-cyano-3-fluorophenyl)methylene)-2-methylpropane-2-sulfinamide

生成物 1

HCID 585794991-(5-Bromo-2-fluorophenyl)-4-fluoro-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine収率 15%

実験手順

The title compound was synthesized as described for Example 14i in 15% yield, starting from N-((5-bromo-2-fluorophenyl)(2-cyano-3-fluorophenyl)methylene)-2-methylpropane-2-sulfinamide (100 mg, 0.24 mmol) and 4-bromo-2-methylpyridine (44.5 mg, 0.26 mmol). Purification was achieved by preparative HPLC.

後処理

  1. customPurification

出典と根拠

ORDレコード
ord-fd33b6173bd145b0a72e8726043b4146
出典データセット
uspto-grants-2011_10
特許番号
US08030500B2

反応ノート

読み込み中…