Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromo-2-(trifluoromethyl)pyridine → 1-(3-Bromo-4-fluorophenyl)-4-fluoro-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromo-2-(trifluoromethyl)pyridine | HCID 23436950 | — |
| 반응물 | N-((3-Bromo-4-fluorophenyl)(2-cyano-3-fluorophenyl)methylene)-2-methylpropane-2-sulfinamide | HCID 76821603 | — |
| 생성물 | 1-(3-Bromo-4-fluorophenyl)-4-fluoro-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine | HCID 58579492 | 35% |
반응 단계
The title compound was synthesized as described for Example 11i in 35% yield, starting from of 4-bromo-2-(trifluoromethyl)pyridine (0.159 g, 0.71 mmol) and N-((3-bromo-4-fluorophenyl)(2-cyano-3-fluorophenyl)methylene)-2-methylpropane-2-sulfinamide (0.300 g, 0.71 mmol);
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08030500B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-43a7f26a90664f13850d6f37faccd8d0 |
| 출처 메모 | uspto-grants-2011_10 |