Benzoyl chloride, 3-bromo- → 2-(3-Bromobenzoyl)-4-chloro-6-fluorobenzonitrile

HRID 1662224Notes

Reaction equation

HRID 1662224 reaction equation
Br[C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([F:11])[C:3]=1[C:4]#[N:5].[Br:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)[C:16](Cl)=[O:17]>>[Br:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)[C:16]([C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([F:11])[C:3]=1[C:4]#[N:5])=[O:17]

Participants

3

Reactant 2

HCID 74377Benzoyl chloride, 3-bromo-HCID 585795372-Bromo-4-chloro-6-fluorobenzonitrile

Product 1

HCID 585795152-(3-Bromobenzoyl)-4-chloro-6-fluorobenzonitrileYield 55%

Procedure

The title compound was synthesized as described for Example 64i in 55% yield starting from 2-bromo-4-chloro-6-fluorobenzonitrile (6.35 g, 27.08 mmol) and 3-bromobenzoyl chloride (3.58 mL, 27.08 mmol).

Sources & evidence

ORD record
ord-488c2ba9bca44412af6aa59767fb8c3e
Source dataset
uspto-grants-2011_10
Patent number
US08030500B2

Reaction notes

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