HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyanopyridine-3-boronic acid → 5-(3-(3-Amino-4-fluoro-1-(2-methylpyridin-4-yl)-1H-isoindol-1-yl)-4-fluorophenyl)nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyanopyridine-3-boronic acid | HCID 45079576 | — |
| Reactant | 1-(5-Bromo-2-fluorophenyl)-4-fluoro-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine | HCID 58579499 | — |
| Product | 5-(3-(3-Amino-4-fluoro-1-(2-methylpyridin-4-yl)-1H-isoindol-1-yl)-4-fluorophenyl)nicotinonitrile | HCID 46205639 | 38% |
Reaction Steps
The title compound was synthesized as described for Example 1 in 38% yield, starting from 1-(5-bromo-2-fluorophenyl)-4-fluoro-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine (80 mg, 0.19 mmol) and 5-cyanopyridin-3-ylboronic acid (37.1 mg, 0.25 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030500B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-aa1723831e0a46da8881a713608f50c5 |
| Source note | uspto-grants-2011_10 |