HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinylboronic acid → 4-Fluoro-1-(2-fluoro-5-(pyridin-3-yl)phenyl)-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinylboronic acid | HCID 2734378 | — |
| Reactant | 1-(5-Bromo-2-fluorophenyl)-4-fluoro-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine | HCID 58579499 | — |
| Product | 4-Fluoro-1-(2-fluoro-5-(pyridin-3-yl)phenyl)-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine | HCID 46205641 | 37% |
Reaction Steps
The title compound was synthesized as described for Example 1 in 37% yield, starting from 1-(5-bromo-2-fluorophenyl)-4-fluoro-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine (80 mg, 0.19 mmol) and pyridin-3-ylboronic acid (30.9 mg, 0.25 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030500B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-2645985829734a07ab08026f319944ef |
| Source note | uspto-grants-2011_10 |