HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Chlorophenyl)boronic acid → 1-(3'-Chlorobiphenyl-3-yl)-4-fluoro-1-(pyridin-4-yl)-1H-isoindol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Chlorophenyl)boronic acid | HCID 2734323 | — |
| Reactant | 1-(3-bromophenyl)-4-fluoro-1-(pyridin-4-yl)-1H-isoindol-3-amine | HCID 58579485 | — |
| Product | 1-(3'-Chlorobiphenyl-3-yl)-4-fluoro-1-(pyridin-4-yl)-1H-isoindol-3-amine | HCID 46205966 | 38% |
Reaction Steps
The title compound was synthesized as described for Example 1 in 38% yield, starting from 1-(3-bromophenyl)-4-fluoro-1-(pyridin-4-yl)-1H-isoindol-3-amine (80 mg, 0.21 mmol) and 3-chlorophenylboronic acid (39.3 mg, 0.25 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030500B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-8250c9521cf84ecdb07dbc843fb3138a |
| Source note | uspto-grants-2011_10 |