2-Fluoro-3-methoxyphenylboronic acid → 4-Fluoro-1-(2'-fluoro-3'-methoxybiphenyl-3-yl)-1-(pyridin-4-yl)-1H-isoindol-3-amine

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Reaction Steps

The title compound was synthesized as described for Example 1 in 28% yield, starting from 1-(3-bromophenyl)-4-fluoro-1-(pyridin-4-yl)-1H-isoindol-3-amine (0.096 g, 0.25 mmol) and 2-fluoro-3-methoxybenzeneboronic acid (0.047 g, 0.28 mmol): 1H NMR (DMSO-d6) δ ppm 8.50-8.44 (m, 2 H) 7.65-7.60 (m, 1 H) 7.58-7.49 (m, 1 H) 7.45-7.37 (m, 3 H) 7.36-7.24 (m, 4 H) 7.22-7.11 (m, 2 H) 6.96-6.90 (m, 1 H) 6.64 (br. s., 2H) 3.85 (s, 3 H), MS (ES+) m/z 428 [M+1]+.

Provenance & Evidence