HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → 4-Fluoro-1-(3-(5-fluoropyridin-3-yl)phenyl)-1-(pyridin-4-yl)-1H-isoindol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | HCID 16414268 | — |
| Reactant | 1-(3-bromophenyl)-4-fluoro-1-(pyridin-4-yl)-1H-isoindol-3-amine | HCID 58579485 | — |
| Product | 4-Fluoro-1-(3-(5-fluoropyridin-3-yl)phenyl)-1-(pyridin-4-yl)-1H-isoindol-3-amine | HCID 46206294 | 25% |
Reaction Steps
The title compound was synthesized as described for Example 1 in 25% yield, starting from 1-(3-bromophenyl)-4-fluoro-1-(pyridin-4-yl)-1H-isoindol-3-amine (0.096 g, 0.25 mmol) and 3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (0.061 g, 0.28 mmol):
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030500B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-78a6da21cf184b10a36d545761d383f2 |
| Source note | uspto-grants-2011_10 |