HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Pyrimidin-5-yl)boronic acid → 4-Fluoro-1-(4-methoxyphenyl)-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Pyrimidin-5-yl)boronic acid | HCID 2795193 | — |
| Reactant | 1-(3-Bromophenyl)-4-fluoro-1-(4-methoxyphenyl)-1H-isoindol-3-amine | HCID 58579518 | — |
| Product | 4-Fluoro-1-(4-methoxyphenyl)-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine | HCID 46206296 | 59% |
Reaction Steps
The title compound was synthesized as described for Example 1 in 59% yield, starting from 1-(3-bromophenyl)-4-fluoro-1-(4-methoxyphenyl)-1H-isoindol-3-amine (0.13 g, 0.25 mmol) and 5-pyrimidinylboronic acid (0.037 g, 0.30 mmol):
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030500B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-eb354066da0040f6afd5e06143a46d03 |
| Source note | uspto-grants-2011_10 |