Dimethylformamide → 4-Fluoro-1-(2-methoxypyridin-4-yl)-1-(3-(pyrazin-2-yl)phenyl)-1H-isoindol-3-amine acetate

Participants

Reaction Steps

1-(3-Bromophenyl)-4-fluoro-1-(2-methoxypyridin-4-yl)-1H-isoindol-3-amine (0.150 g, 0.36 mmol), 2-(tributylstannyl)pyrazine (0.120 mL, 0.38 mmol), tetrakis(triphenylphosphine)palladium(0) (0.042 g, 0.04 mmol) and DMF (4 mL) were put in microwave vial and irradiated in a microwave reactor at 150° C. for 20 min. The resulting product mixture was filtered and purified by preparative-HPLC to give the title compound 0.083 g, (48.5% yield).

Provenance & Evidence