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Pyridine, 4-methoxy-2-(tributylstannyl)- → 4-Fluoro-1-(3-(4-methoxypyridin-2-yl)phenyl)-1-(2-methoxypyridin-4-yl)-1H-isoindol-3-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine, 4-methoxy-2-(tributylstannyl)- | HCID 57516635 | — |
| 反応物 | 1-(3-Bromophenyl)-4-fluoro-1-(2-methoxypyridin-4-yl)-1H-isoindol-3-amine | HCID 58579498 | — |
| 生成物 | 4-Fluoro-1-(3-(4-methoxypyridin-2-yl)phenyl)-1-(2-methoxypyridin-4-yl)-1H-isoindol-3-amine | HCID 46202413 | 13% |
反応手順
The title compound was synthesized as described in Example 29 in 13% yield starting from 1-(3-bromophenyl)-4-fluoro-1-(2-methoxypyridin-4-yl)-1H-isoindol-3-amine (0.150 g, 0.36 mmol) and 4-methoxy-2-(tributylstannyl)pyridine (0.188 g, 0.47 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08030500B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-c3ed224c420349fe912fd2a9b3288046 |
| 出典メモ | uspto-grants-2011_10 |