反应详情

温度

150 °C

1-(2-Bromopyridin-4-yl)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1H-isoindol-3-amine (64 mg, 0.15 mmol), 5-pyrimidinylboronic acid (23.80 mg, 0.19 mmol), [1,1′-bis (diphenylphosphino)ferrocene]palladium(II) chloride (6.03 mg, 7.39 μmol), cesium carbonate (0.035 mL, 0.44 mmol) and DME:EtOH:water (6:3:1) (3.00 mL) were put in a microwave vial and heated at 150° C. in a microwave reactor for 20 min. The reaction mixture was filtered through a syringe filter and purified by prep-HPLC. The desired fractions were pooled and freeze dried over night to give the title compound (25.7 mg, 39%).

1. filtrationThe reaction mixture was filtered through a syringe
2. filtrationfilter
3. custompurified by prep-HPLC
4. customfreeze dried over night