HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Pyrimidin-5-yl)boronic acid → 4-Fluoro-1-(4-fluoro-3-methoxyphenyl)-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Pyrimidin-5-yl)boronic acid | HCID 2795193 | — |
| Reactant | 1-(3-Bromophenyl)-4-fluoro-1-(4-fluoro-3-methoxyphenyl)-1H-isoindol-3-amine | HCID 58579521 | — |
| Product | 4-Fluoro-1-(4-fluoro-3-methoxyphenyl)-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine | HCID 46203072 | 20% |
Reaction Steps
The title compound was synthesized as described for Example 45 in 20% yield starting from 1-(3-bromophenyl)-4-fluoro-1-(4-fluoro-3-methoxyphenyl)-1H-isoindol-3-amine (210 mg, 0.49 mmol) and pyrimidine-5-boronic acid (72.7 mg, 0.59 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030500B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-33323cf2466647df8f082b8e972d3f05 |
| Source note | uspto-grants-2011_10 |