(Pyrimidin-5-yl)boronic acid → 4-Fluoro-1-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine

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Reaction Steps

The title compound was synthesized as described for Example 1 in 79% yield, starting from 1-(3-bromophenyl)-4-fluoro-1-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-1H-isoindol-3-amine (680 mg, 1.42 mmol), pyrimidin-5-ylboronic acid (211 mg, 1.70 mmol). 1H NMR (400 MHz, DMSO-d6) δ ppm 9.18 (s, 1 H) 9.05 (s, 2 H) 8.41 (d, 1 H) 7.91 (d, 1 H) 7.87 (d, 1 H) 7.66-7.72 (m, 2 H) 7.56 (td, 1 H) 7.44-7.52 (m, 2 H) 7.28 (dd, 1 H) 6.72 (br. s., 2 H) 3.94 (s, 3 H); MS (ES+) m/z 480 [M+1]+.

Provenance & Evidence