HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-5-methoxyphenylboronic acid → Methyl 3-(3-(((2-methyl-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-5-methoxyphenylboronic acid | HCID 4157211 | — |
| Reactant | Methyl 3-(3-(((4-bromo-3-methylphenyl)methyl)oxy)phenyl)propanoate | HCID 57705740 | — |
| Product | Methyl 3-(3-(((2-methyl-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate | HCID 57705995 | 92.9% |
Reaction Steps
Compound 1.3 (0.070 g, 0.193 mmol) was coupled with 2-fluoro-5-methoxyphenylboronic acid (available from Aldrich) (0.0982 g, 0.578 mmol) according to the method reported for preparation of 1.4 to afford 2.1 (0.070 g, 89%) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030354B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-88b472fc63ea4553b5716a34c08a5381 |
| Source note | uspto-grants-2011_10 |