HCID 57706034, compound → HCID 57706716, compound

HRID 1662324Notes

Reaction equation

HRID 1662324 reaction equation
[F:1][C:2]([F:18])([F:17])/[C:3](/[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[CH:4]\[C:5]([O:7][CH3:8])=[O:6]>CCOC(C)=O.CO>[F:1][C:2]([F:17])([F:18])[CH:3]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)[CH2:4][C:5]([O:7][CH3:8])=[O:6]

Participants

3

Reactant 1

HCID 57706034HCID 57706034, compound

Product 1

HCID 57706716HCID 57706716, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

A 250 mL flask containing a solution of 6.1 (2.20 g, 8.5 mmol) in 1:1 EtOAc/MeOH (40 mL) was purged with N2. To the mixture was added palladium, 10 wt. % (dry), on carbon powder, wet (0.90 g, 0.85 mmol). The vial was then purged with H2, and the contents were stirred overnight under a H2 balloon. The black mixture was filtered through a pad of Celite and concentrated to afford 6.2 (2.19 g, 99% yield).

Workup

  1. customwas purged with N2
  2. additionTo the mixture was added
  3. dry with materialpalladium, 10 wt. % (dry)
  4. customThe vial was then purged with H2
  5. filtrationThe black mixture was filtered through a pad of Celite
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-579d41fec54e4bb39873ca8eeb1aaddf
Source dataset
uspto-grants-2011_10
Patent number
US08030354B2

Reaction notes

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