HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Bromo-5-(chloromethyl)phenyl butyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (4-Bromo-3-(butyloxy)phenyl)methanol | HCID 57705850 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Bromo-5-(chloromethyl)phenyl butyl ether | HCID 57706305 | 92% |
Reaction Steps
To a stirred solution of 20.2 (659.3 mg, 2544 μmol) in DCM (15 mL) at 23° C., was added thionyl chloride (371 μL, 5088 μmol). The resulting mixture was stirred overnight. The reaction was concentrated and then purified by combiflash (0 to 10% EtOAc/Hexanes) to provide 20.3 (650 mg, 92.0% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030354B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-196a25fc8e724315a14d556eab312c94 |
| Source note | uspto-grants-2011_10 |