HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3'-Hydroxyphenyl)propionic acid → 3-(3-(4-Chloro-3-(trifluoromethoxy)benzyloxy)phenyl)-propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3'-Hydroxyphenyl)propionic acid | HCID 91 | — |
| Reactant | 4-Chloro-3-(trifluoromethoxy)benzyl bromide | HCID 17750697 | — |
| Product | 3-(3-(4-Chloro-3-(trifluoromethoxy)benzyloxy)phenyl)-propanoic acid | HCID 57706011 | — |
Reaction Steps
Compound 37.3 was synthesized using the alkylation and hydrolysis procedure of Example 13 above using compounds 37.1 and 37.2. 3-(3-Hydroxyphenyl)propanoic acid is available from Alfa Aesar Avocado, and Lancaster). 4-(Bromomethyl)-1-chloro-2-(trifluoromethoxy)benzene is available from Alfa Aesar, Lancaster, and Avocado. MS ESI (neg.) m/e: 373 (M−H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030354B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-c6765633e95b440293be8f46c3b477f5 |
| Source note | uspto-grants-2011_10 |