HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Methoxyphenyl)boronic acid → 3-[3-(3'-Methoxy-2-trifluoromethoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Methoxyphenyl)boronic acid | HCID 2734370 | — |
| Reactant | 3-(3-(4-Chloro-3-(trifluoromethoxy)benzyloxy)phenyl)-propanoic acid | HCID 57706011 | — |
| Product | 3-[3-(3'-Methoxy-2-trifluoromethoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid | HCID 57706069 | — |
Reaction Steps
Compound 37 was synthesized using the procedure above for preparing 13.3 using compound 37.3 and 3-methoxyphenylboronic acid 37.4 (available from Aldrich). MS ESI (neg.) m/e: 445 (M−H). 1H NMR (400 MHz, CD3CN) δ ppm 7.51 (3H, s), 7.38 (1H, s), 7.22 (1H, s), 7.05 (2H, s), 6.98 (1H, s), 6.87 (3H, s), 5.15 (2H, s), 3.81 (3H, s), 2.86 (2H, s), 2.59 (2H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030354B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-0d78d63d3c9b4c1e8b21181a2835e8e2 |
| Source note | uspto-grants-2011_10 |