HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-5-methoxyphenylboronic acid → 3-[3-(2'-Fluoro-5'-methoxy-2-trifluoromethoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-5-methoxyphenylboronic acid | HCID 4157211 | — |
| Reactant | 3-(3-(4-Chloro-3-(trifluoromethoxy)benzyloxy)phenyl)-propanoic acid | HCID 57706011 | — |
| Product | 3-[3-(2'-Fluoro-5'-methoxy-2-trifluoromethoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid | HCID 57706177 | — |
Reaction Steps
Compound 38 was synthesized using the procedure described above for preparing 13.3 using compound 37.3 and 2-fluoro-5-methoxyphenylboronic acid 38.1 (available from Aldrich). MS ESI (neg.) m/e: 463 (M−H). 1H NMR (400 MHz, CD3CN) δ ppm 7.47-7.54 (3H, m), 7.22 (1H, t, J=7.8 Hz), 7.12-7.17 (1H, m), 6.98 (1H, dt, J=9.0, 3.5 Hz), 6.90-6.93 (2H, m), 6.85 (2H, dd, J=8.0, 2.2 Hz), 5.16 (2H, s), 3.79 (3H, s), 2.86 (2H, s), 2.56-2.62 (2H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030354B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-ec0a0fb1b04940a59ac791651255e21f |
| Source note | uspto-grants-2011_10 |