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HRID16624

反应详情

EQUATION

反应方程式

HRID 16624 的结构方程式

REACTANTS

反应物

2
结构：C[O-].[Na+]
HCID10942334

Methanol, sodium salt

CH3NaO

2 次

结构：CCn1nnc([C@H]2O[C@@H](n3cnc4c(N[C@H]5CC[C@H](Nc6nc(NCCc7cn(C)cn7)nc7c6ncn7[C@@H]6O[C@H](c7nnn(CC)n7)[C@@H](OC(C)=O)[C@H]6OC(C)=O)CC5)nc(NCCc5cn(C)cn5)nc43)[C@H](OC(C)=O)[C@@H]2OC(C)=O)n1
HCID178463184

未命名化合物

PRODUCTS

生成物

1
结构：CCn1nnc([C@H]2O[C@@H](n3cnc4c(N[C@H]5CC[C@H](Nc6nc(NCCc7cn(C)cn7)nc7c6ncn7[C@@H]6O[C@H](c7nnn(CC)n7)[C@@H](O)[C@H]6O)CC5)nc(NCCc5cn(C)cn5)nc43)[C@H](O)[C@@H]2O)n1
HCID178463185

未命名化合物

收率 97.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of Stage 3 (28.6 g; assume 24.7 mmol) in methanol (515 ml) was treated with sodium methoxide (0.44 g, 8.13 mmol) for 90 minutes before being treated with a further portion of sodium methoxide (0.44 g, 8.13 mmol). After 30 minutes Dowex 50 [H+] was added to neutralise the solution. The resin was filtered off and the filtrate was evaporated to leave the title Compound as a foam (24 g).

WORKUP

后处理

  1. additionAfter 30 minutes Dowex 50 [H+] was added
  2. filtrationThe resin was filtered off
  3. customthe filtrate was evaporated