2'-Fluoro-2-(1-hydroxy-2,2-dimethyl-but-3-enyl)-5'-methoxy-biphenyl-4-carboxylic acid methyl ester → Methyl 2'-fluoro-2-(1-hydroxy-2,2-dimethylbutyl)-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

Participants

Reaction Steps

To a solution of 66.60D (0.453 g, 1.26 mmol) in MeOH (10 mL) (degassed by N2), was added palladium on carbon (0.135 g, 1.26 mmol). The resulting mixture was stirred at room temperature under H2 for 18 hrs. The reaction mixture was then filtered through silica gel. After removing solvent, 66.62A (394 mg) was obtained as a colorless oil.

Provenance & Evidence