HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-((4-(Chloromethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-2-yl)methyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2'-Fluoro-5'-(methyloxy)-2-(1-piperidinylmethyl)-1,1'-biphenyl-4-yl)methanol | HCID 57706303 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-((4-(Chloromethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-2-yl)methyl)piperidine | HCID 57705707 | 100% |
Reaction Steps
Thionyl chloride (0.066 g, 0.56 mmol) was added to a solution of 66.64B (0.023 g, 0.070 mmol) in DCM (1 mL). The resulting mixture was stirred at room temperature for 2 hours. After removing solvent, 66.64C was obtained in 100% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030354B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-68773ba84fe94786a083376d3a629c7d |
| Source note | uspto-grants-2011_10 |