(3-(5,5-Dimethylcyclopent-1-enyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol → 4-Chloromethyl-2-cyclopent-1-enyl-2'-fluoro-5'-methoxy-biphenyl

Participants

Role	Name	HCID	Charge
Reactant	(3-(5,5-Dimethylcyclopent-1-enyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol	HCID 57467619	—
Reactant	4-(4-(Chloromethyl)-2-(5,5-dimethylcyclopent-1-enyl)phenyl)-5-fluoro-2-methoxypyridine	HCID 57467620	—
Reactant	[2'-Fluoro-5'-methoxy-2-(1-methoxy-cyclopentyl)-biphenyl-4-yl]-methanol	HCID 57706279	—
Product	4-Chloromethyl-2-cyclopent-1-enyl-2'-fluoro-5'-methoxy-biphenyl	HCID 57705676	—

Reaction Steps

Compound 66.68G was synthesized from 66.68F using a method analogous to the method used to prepare compound 66.12D from 66.12C. MS ESI m/e: 317.1 (M+1)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08030354B2
Source dataset	uspto-grants-2011_10
ORD ID	ord-da2487fb1e3e4b8a91d11608e91129e1
Source note	uspto-grants-2011_10