Sodium Hydroxide → HCID 57705618, compound

Participants

Reaction Steps

To a stirred solution of 78.7D (0.260 g, 0.7 mmol) in THF (7 mL) at 0° C. was added LAH (1 mL, 1 mmol, 1.0M). The reaction was stirred for one hour and then 1N NaOH was added to quench the reaction. The resulting solution was extracted three times with EtOAc. After drying over anhydrous magnesium sulfate and filtering, the organic solvent was removed under reduced pressure and the product was purified on silica gel (0-20% EtOAc in hexanes) to yield 78.7E as a colorless oil (0.192 g, 80% yield). MS ESI (pos.) m/e: 311.2 (M−OH)+.

Provenance & Evidence