Potassium Carbonate → HCID 57706728, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 83.26C (0.500 g, 1.2 mmol) in DMF (6.1 mL) at 23° C. was added 2-methylprop-1-enylboronic acid (0.24 g, 2.4 mmol, commercially available from Synthonix), and potassium carbonate (0.51 g, 3.7 mmol). Tetrakis(triphenylphosphine)palladium (0.071 g, 0.061 mmol) was then added to the mixture. The mixture was heated to 90° C. and stirred for 15 hours. The reaction was then cooled to room temperature, diluted with brine and extracted three times with EtOAc. After drying over anhydrous magnesium sulfate and filtering, the organic solvent was removed under reduced pressure and the product was then purified on silica gel (0-10% EtOAc in hexanes) to yield 83.26D as a colorless oil (0.280 g, 73% yield).

Provenance & Evidence