反应详情

To a solution of methyl methoxyacetate (available from Aldrich) (0.48 mL, 4.8 mmol) in ether (20 mL) was added 3-benzyloxyphenylmagnesium bromide (1.0 M in THF) (available from Aldrich) (5.0 mL, 5.0 mmol) dropwise at −78° C. The mixture was warmed to room temperature overnight, quenched with 1 N HCl, and diluted with EtOAc. The organic layers were washed with water and brine, dried (MgSO4), and concentrated. The crude product was purified by silica gel flash chromatography (0-20% EtOAc/hexane) to afford 102.A (0.17 g, 14% yield) as a pale yellow oil.

1. customquenched with 1 N HCl
2. additiondiluted with EtOAc
3. washThe organic layers were washed with water and brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. customThe crude product was purified by silica gel flash chromatography (0-20% EtOAc/hexane)