2,5-Bis(2,2,2-trifluoroethoxy)benzene-1-sulfonyl chloride → (4R)-1-[1-{[2,5-bis (2,2,2-trifluoroethoxy)phenyl]sulfonyl}-5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-in dol-3-yl]-4-hydroxy-N,N-dimethyl-L-prolinamide

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Reaction Steps

With 100 mg of (4R)-1-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-L-prolinamide (levorotatory isomer), which is the compound described in Preparation 3.2 (Isomer B) of the brochure Publication No. WO01/55130, and 89 mg of 2,5-bis (2,2,2-trifluoroethoxy)benzene sulfonyl chloride as starting materials, 119 mg of the title compound (colorless amorphous) was obtained by a similar method to Example 2.

Provenance & Evidence