3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → (4R)-1-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-fluoro-N,N-dimethy l-L-prolinamide

Participants

Reaction Steps

With 3.78 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 6-3 (13.5 mmol) as starting materials, respectively 2.06 g (Isomer A: colorless powder) and 2.74 g (Isomer B: colorless powder) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Provenance & Evidence