3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → 3-[(2S)-2-(azetidin-1-ylcarbonyl)-4-fluoropyrrolidin-1-yl]-5-chloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Participants

Reaction Steps

With 2.37 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 10-3 (3.82 g, crude form) as starting materials, respectively 874 mg (Isomer A: colorless solid) and 1.45 g (Isomer B: colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Provenance & Evidence