HCID 67428575, compound → HCID 45115932, compound

HRID 1662602Notes

Reaction equation

HRID 1662602 reaction equation
[CH2:1]([NH:3][C:4]([C@@H:6]1[CH2:10][CH:9]([F:11])[CH2:8][N:7]1C(OCC1C=CC=CC=1)=O)=[O:5])[CH3:2]>CO.[C].[Pd]>[CH2:1]([NH:3][C:4](=[O:5])[C@@H:6]1[CH2:10][CH:9]([F:11])[CH2:8][NH:7]1)[CH3:2]

Participants

4

Reactant 1

HCID 67428575HCID 67428575, compound

Product 1

HCID 45115932HCID 45115932, compoundYield 109.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Under hydrogen atmosphere, a suspension of 1.80 g of the compound obtained in Step 11-3 and 360 mg of 10% palladium-carbon in MeOH (36 ml) was stirred at room temperature for 3 hours. From the stirred solution, insoluble matter was separated by filtration, the solution was concentrated under reduced pressure to obtain 1.07 g of the title compound. The present compound was used in the next reaction without purification.

Workup

  1. customFrom the stirred solution, insoluble matter was separated by filtration
  2. concentrationthe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8caa4e03bd8a46abaff85a77e8cfb62e
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

Loading…