3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 67428596, compound

HRID 1662603Notes

Reaction equation

HRID 1662603 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].[CH2:21]([NH:23][C:24](=[O:31])[C@@H:25]1[CH2:29][CH:28]([F:30])[CH2:27][NH:26]1)[CH3:22]>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([N:26]1[CH2:27][CH:28]([F:30])[CH2:29][C@H:25]1[C:24]([NH:23][CH2:21][CH3:22])=[O:31])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 45115932HCID 45115932, compound

Product 1

HCID 67428596HCID 67428596, compound

Procedure

With 1.02 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and 530 mg of the compound obtained in Step 11-4 as starting materials, respectively 708 mg (Isomer A: colorless amorphous) and 501 mg (Isomer B: colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-3f19cc3d83d14a02bb8831333c4867c9
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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