3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 67428740, compound

HRID 1662604Notes

Reaction equation

HRID 1662604 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].[F:21][CH:22]1[CH2:26][NH:25][C@H:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23]1>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([N:25]1[CH2:26][CH:22]([F:21])[CH2:23][C@H:24]1[C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 57217836HCID 57217836, compound

Product 1

HCID 67428740HCID 67428740, compound

Procedure

With 1.06 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and 685 mg of the compound obtained in Step 12-2 as starting materials, respectively 678 mg (Isomer A: colorless solid) and 839 mg (Isomer B: colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-c517618588714f24bfc65681bbed37b4
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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