HRID1662610

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccccc1C1(N2CC(O)C(O)[C@H]2C(=O)N(C)C)C(=O)Nc2ccc(Cl)cc21

HCID67428001

未命名化合物

HCID86625684

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(S(=O)(=O)N2C(=O)C(c3ccccc3OC)(N3CC(O)C(O)[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC(F)(F)F)c1

HCID59867771

未命名化合物

收率 52.7%

PROCEDURE

实验过程

With 300 mg of the compound obtained in Step 19-7 and 215 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting material, 248 mg of the title compound (colorless amorphous) was obtained by a similar method to Example 2.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4988a15719a444beae9b0d3afea5081d
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030499B2
来源说明: uspto-grants-2011_10

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([N:20]1[CH2:29][CH:28]([OH:30])[CH:27]([OH:31])[C@H:21]1[C:22]([N:24]([CH3:26])[CH3:25])=[O:23])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19].[CH3:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([S:40](Cl)(=[O:42])=[O:41])=[C:36]([O:44][C:45]([F:48])([F:47])[F:46])[CH:35]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:40]([C:37]1[CH:38]=[CH:39][C:34]([O:33][CH3:32])=[CH:35][C:36]=1[O:44][C:45]([F:46])([F:47])[F:48])(=[O:42])=[O:41])[C:6](=[O:11])[C:5]2([N:20]1[CH2:29][CH:28]([OH:30])[CH:27]([OH:31])[C@H:21]1[C:22]([N:24]([CH3:26])[CH3:25])=[O:23])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19]