(2S)-1-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N,N-dimethylpiperidine-2-carboxamide → (2S)-1-(5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-N,N-dimethylpiperidine-2-carboxamide

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Reaction Steps

With 500 mg of (2S)-1-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N,N-dimethylpiperidine-2-carboxamide, which is the compound described in Preparation 3.49 (Isomer B) of Publication No. WO01/98295 and 374 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 322 mg of the title compound (colorless amorphous) was obtained by a similar method to Example 2.

Provenance & Evidence