HRID1662621

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccccc1C1(N2CCCC[C@H]2C(=O)N(C)C)C(=O)Nc2ccc(Cl)cc21

HCID67429052

未命名化合物

HCID71744215

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1C1(N2CCCC[C@H]2C(=O)N(C)C)C(=O)N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2OC)c2ccc(Cl)cc21

HCID11951803

未命名化合物

收率 44.7%

PROCEDURE

实验过程

With 303 mg of (2S)-1-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N,N-dimethylpiperidine-2-carboxamide, which is the compound described in Preparation 3.49 (Isomer B) of the brochure Publication No. WO01/98295 and 245 mg of 2-methoxy-4-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 216 mg of the title compound (colorless amorphous) was obtained by a similar method to Example 1.

WORKUP

后处理

customdescribed in Preparation 3.49 (Isomer B) of the brochure Publication No

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-195b9130697a425fa3526fc349e5b90c
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030499B2
来源说明: uspto-grants-2011_10

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([N:20]1[CH2:25][CH2:24][CH2:23][CH2:22][C@H:21]1[C:26]([N:28]([CH3:30])[CH3:29])=[O:27])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19].[CH3:31][O:32][C:33]1[CH:38]=[C:37]([O:39][C:40]([F:43])([F:42])[F:41])[CH:36]=[CH:35][C:34]=1[S:44](Cl)(=[O:46])=[O:45]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:44]([C:34]1[CH:35]=[CH:36][C:37]([O:39][C:40]([F:41])([F:42])[F:43])=[CH:38][C:33]=1[O:32][CH3:31])(=[O:45])=[O:46])[C:6](=[O:11])[C:5]2([N:20]1[CH2:25][CH2:24][CH2:23][CH2:22][C@H:21]1[C:26]([N:28]([CH3:29])[CH3:30])=[O:27])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19]