5-chloro-3-(2-methoxyphenyl)-3-[2-oxo-2-(4-pyrazine-2-ylpiperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one → 5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-3-[2-oxo-2-(4-pyrazine-2-ylpiperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one

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With 300 mg of 5-chloro-3-(2-methoxyphenyl)-3-[2-oxo-2-(4-pyrazine-2-ylpiperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one, which is the compound described in Composes IV.1 of the brochure Publication No. WO03/008407, and 201 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 424 mg of the title compound (pale yellow amorphous) was obtained by a similar method to Example 2.

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