HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67428163, compound → 5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-3-[2-oxo-2-(4-pyrimidin-2-ylpiperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67428163 | HCID 67428163 | — |
| Reactant | 4-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride | HCID 86625684 | — |
| Product | 5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-3-[2-oxo-2-(4-pyrimidin-2-ylpiperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one | HCID 11951264 | 87.5% |
Reaction Steps
With 300 mg of the compound obtained in Step 45-1 and 201 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 402 mg of the title compound (colorless amorphous) was obtained by a similar method to Example 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030499B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-a0a20496492d4955affcc191996a408e |
| Source note | uspto-grants-2011_10 |