HRID1662631

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccccc1C1(CC(=O)N2CCN(c3nccs3)CC2)C(=O)Nc2ccc(Cl)cc21

HCID67430051

未命名化合物

HCID86625684

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(S(=O)(=O)N2C(=O)C(CC(=O)N3CCN(c4nccs4)CC3)(c3ccccc3OC)c3cc(Cl)ccc32)c(OC(F)(F)F)c1

HCID11951096

未命名化合物

收率 89.3%

PROCEDURE

实验过程

With 300 mg of the compound obtained in Step 46-1 and 200 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 409 mg of the title compound (yellow amorphous) was obtained by a similar method to Example 2.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-612c011bf1b5407389183f0e70ca6420
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030499B2
来源说明: uspto-grants-2011_10

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[O:32][CH3:33])[CH2:12][C:13](=[O:25])[N:14]1[CH2:19][CH2:18][N:17]([C:20]2[S:21][CH:22]=[CH:23][N:24]=2)[CH2:16][CH2:15]1.[CH3:34][O:35][C:36]1[CH:41]=[CH:40][C:39]([S:42](Cl)(=[O:44])=[O:43])=[C:38]([O:46][C:47]([F:50])([F:49])[F:48])[CH:37]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:42]([C:39]1[CH:40]=[CH:41][C:36]([O:35][CH3:34])=[CH:37][C:38]=1[O:46][C:47]([F:48])([F:49])[F:50])(=[O:44])=[O:43])[C:6](=[O:11])[C:5]2([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[O:32][CH3:33])[CH2:12][C:13](=[O:25])[N:14]1[CH2:15][CH2:16][N:17]([C:20]2[S:21][CH:22]=[CH:23][N:24]=2)[CH2:18][CH2:19]1