HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-chloro-3-(2-methoxyphenyl)-3-[2-oxo-2-(4-pyridazin-3-ylpiperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one → 5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-3-[2-oxo-2-(4-pyridazin-3-ylpiperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-chloro-3-(2-methoxyphenyl)-3-[2-oxo-2-(4-pyridazin-3-ylpiperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one | HCID 67429841 | — |
| Reactant | 4-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride | HCID 86625684 | — |
| Product | 5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-3-[2-oxo-2-(4-pyridazin-3-ylpiperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one | HCID 11951091 | 75.3% |
Reaction Steps
With 170 mg of the compound obtained in Step 49-1 and 114 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 196 mg of the title compound (colorless amorphous) was obtained by a similar method to Example 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030499B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-5035c5cd57b1448da6c4c16c417be831 |
| Source note | uspto-grants-2011_10 |