5-chloro-3-(2-methoxyphenyl)-3-[2-oxo-2-(4-pyridin-4-yl piperidin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one → 5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-3-[2-oxo-2-(4-pyridin-4-yl piperidin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one

Participants

Reaction Steps

With 290 mg of the compound obtained in Step 51-2 and, 202 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 150 mg of the title compound (colorless amorphous) was obtained by a similar method to Example 2.

Provenance & Evidence