Sodium Hydroxide → HCID 67427964, compound

HRID 1662642Notes

Reaction equation

HRID 1662642 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([O:20][CH2:21][C:22]([O:24]C)=[O:23])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19].[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([O:20][CH2:21][C:22]([OH:24])=[O:23])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86625685HCID 86625685, compound

Product 1

HCID 67427964HCID 67427964, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 8.00 g of the compound obtained in Step 53-1 in MeOH (400 ml) was added an aqueous solution of 1.3 mol/L NaOH, and the reaction mixture was stirred at room temperature for 13 hours. The reaction solution was concentrated, under ice cooling, 3 mol/L hydrochloric acid was added until it became acidic. The obtained suspension was ultrasonicated for one hour, then, the insoluble matter was collected by filtration to obtain 7.31 g of the title compound (pale yellow solid).

Workup

  1. concentrationThe reaction solution was concentrated, under ice cooling
  2. addition3 mol/L hydrochloric acid was added until it
  3. customThe obtained suspension was ultrasonicated for one hour
  4. filtrationthe insoluble matter was collected by filtration

Sources & evidence

ORD record
ord-69737659b7b64e6ea019b3bdf28086a8
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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