HCID 67427795, compound → HCID 11950736, compound

HRID 1662644Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[O:34][CH3:35])[O:12][CH2:13][C:14](=[O:27])[N:15]1[CH2:20][CH2:19][N:18]([C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)[CH2:17][CH2:16]1.[CH3:36][O:37][C:38]1[CH:43]=[CH:42][C:41]([S:44](Cl)(=[O:46])=[O:45])=[C:40]([O:48][C:49]([F:52])([F:51])[F:50])[CH:39]=1>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:44]([C:41]1[CH:42]=[CH:43][C:38]([O:37][CH3:36])=[CH:39][C:40]=1[O:48][C:49]([F:50])([F:51])[F:52])(=[O:46])=[O:45])[C:6](=[O:11])[C:5]2([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[O:34][CH3:35])[O:12][CH2:13][C:14](=[O:27])[N:15]1[CH2:16][CH2:17][N:18]([C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)[CH2:19][CH2:20]1

Participants

Reactant 2

HCID 67427795HCID 67427795, compound

HCID 866256844-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride

Product 1

HCID 11950736HCID 11950736, compound

Procedure

With 300 mg of the compound obtained in Step 55-1 and 201 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 262 mg of free form of the title compound (yellow amorphous) was obtained by a similar method to Example 2. In a similar procedure to Example 43, by subjecting 237 mg of the obtained free form to salt formation and solidification, 211 mg of the title compound (colorless amorphous) was obtained.

Sources & evidence

ORD record: ord-072207a369ac480c812d8c5128e84ffc
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08030499B2

Reaction notes

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