3-Amino-5-chloro-1,3-dihydro-3-(2-methoxyphenyl)indol-2-one → 3-amino-5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-1,3-dihydro-2H-indol-2-one

Participants

Reaction Steps

With 5.54 g of 3-amino-5-chloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one 5.00 g, 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride, which is the compound described in Preparation 1.18A of the brochure Publication No. WO03/008407, as starting materials, 4.99 g of the title compound (light yellow solid) was obtained by a similar method to Example 2.

Provenance & Evidence