3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 67429224, compound

HRID 1662657Notes

Reaction equation

HRID 1662657 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].FC(F)(F)C(O)=O.[NH2:28][C@@H:29]([CH2:35][CH2:36][C:37]([NH2:39])=[O:38])[C:30]([N:32]([CH3:34])[CH3:33])=[O:31]>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([NH:28][C@@H:29]([CH2:35][CH2:36][C:37]([NH2:39])=[O:38])[C:30]([N:32]([CH3:34])[CH3:33])=[O:31])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 86625692HCID 86625692, compound

Product 1

HCID 67429224HCID 67429224, compound

Procedure

With 1.03 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 68-2 (3.66 mmol, crude form) as starting materials, respectively 168 mg (Isomer A, colorless amorphous) and 204 mg (Isomer B, colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-0ded329be4a74f2f8b39777ddd6d545a
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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