3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 67428005, compound

HRID 1662664Notes

Reaction equation

HRID 1662664 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].FC(F)(F)C(O)=O.[NH2:28][C:29]1([C:34]([N:36]([CH3:38])[CH3:37])=[O:35])[CH2:33][CH2:32][CH2:31][CH2:30]1>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([NH:28][C:29]1([C:34]([N:36]([CH3:38])[CH3:37])=[O:35])[CH2:33][CH2:32][CH2:31][CH2:30]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 67429037HCID 67429037, compound

Product 1

HCID 67428005HCID 67428005, compound

Procedure

With 0.81 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 76-3 (2.89 mmol, crude form) as starting materials, 0.27 g of the title compound (pale yellow solid) was obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-2be043b57172479493085ab8eb0e0177
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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