3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 178489366, compound

HRID 1662665Notes

Reaction equation

HRID 1662665 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].FC(F)(F)C(O)=O.[NH2:28][C@@H:29]([CH2:35][C:36]1[N:37]=[CH:38][NH:39][CH:40]=1)[C:30]([N:32]([CH3:34])[CH3:33])=[O:31]>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([NH:28][C@@H:29]([CH2:35][C:36]1[N:37]=[CH:38][NH:39][CH:40]=1)[C:30]([N:32]([CH3:33])[CH3:34])=[O:31])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 178484599HCID 178484599, compound

Product 1

HCID 178489366HCID 178489366, compound

Procedure

With 1.48 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 77-2 (5.28 mmol, crude form) as starting materials, respectively 0.57 g (Isomer A, colorless powder) and 0.88 g (Isomer B, colorless powder) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-22524fc84f184fb89ed0422815631863
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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