HCID 131729221, compound → HCID 131729220, compound

HRID 1662666Notes

Reaction equation

HRID 1662666 reaction equation
C(OC([NH:11][C@H:12]([C:25]([N:27]([CH3:29])[CH3:28])=[O:26])[CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=O)C1C=CC=CC=1.[H][H]>CCO.[Pd]>[C:21]([O:20][C:18](=[O:19])[NH:17][CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]([NH2:11])[C:25]([N:27]([CH3:28])[CH3:29])=[O:26])([CH3:22])([CH3:24])[CH3:23]

Participants

5

Reactant 2

HCID 131729221HCID 131729221, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 131729220HCID 131729220, compoundYield 106.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Under nitrogen atmosphere, palladium-activated carbon (10% Pd, 0.30 g) was added to a solution of 2.75 g of the compound obtained in Step 78-1 in EtOH (30 ml) and the inside of the reaction system was displaced with hydrogen gas. The solution was stirred at room temperature for two hours, then, the reaction solution was filtered, and the solvent was filtered out under reduced pressure to obtain 1.97 g of residue (pale yellow oil). The present compound was used in the next reaction without purification.

Workup

  1. filtrationthe reaction solution was filtered
  2. filtrationthe solvent was filtered out under reduced pressure

Sources & evidence

ORD record
ord-5dfad01c8efc49dea53fe45263b42309
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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