3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 86625699, compound

HRID 1662667Notes

Reaction equation

HRID 1662667 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].[C:21]([O:25][C:26](=[O:39])[NH:27][CH2:28][CH2:29][CH2:30][CH2:31][C@H:32]([NH2:38])[C:33]([N:35]([CH3:37])[CH3:36])=[O:34])([CH3:24])([CH3:23])[CH3:22]>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([NH:38][C@H:32]([C:33]([N:35]([CH3:37])[CH3:36])=[O:34])[CH2:31][CH2:30][CH2:29][CH2:28][NH:27][C:26](=[O:39])[O:25][C:21]([CH3:22])([CH3:23])[CH3:24])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 131729220HCID 131729220, compound

Product 1

HCID 86625699HCID 86625699, compound

Procedure

With 1.73 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 78-2 (6.76 mmol, crude form) as starting materials respectively 0.90 g (Isomer A, colorless amorphous) and 1.69 g (Isomer B, colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-df4d040bdb95467da5689a2e7cc2d3c2
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

Loading…