3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 67429497, compound

HRID 1662674Notes

Reaction equation

HRID 1662674 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].[NH2:21][C@@H:22]([CH2:28][C:29]1[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=1)[C:23]([N:25]([CH3:27])[CH3:26])=[O:24].ClC1C=C2C(=CC=1)N(S(C1C=CC(OC)=CC=1OC(F)(F)F)(=O)=O)C(=O)C2(N[C@@H](CC(N)=O)C(N(C)C)=O)C1C=CC=CC=1OC>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([NH:21][C@@H:22]([CH2:28][C:29]1[CH:30]=[CH:31][N:32]=[CH:33][CH:34]=1)[C:23]([N:25]([CH3:27])[CH3:26])=[O:24])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

4

Reactant 3

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 59867952HCID 59867952, compoundHCID 67430342HCID 67430342, compound

Product 1

HCID 67429497HCID 67429497, compound

Procedure

With 0.78 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and 0.54 g of the compound obtained in Step 83-2 as starting materials, 268 mg of a diastereoisomer mixture of the title compound (pale yellow amorphous) was obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-783eff3a10454d2a8a73352671ea2a4d
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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